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In August 2015, a minor furor broke out on the SIGCIS and Humanist discussion forum about the merits or otherwise of Tara McPherson’s essay “Why Are the Digital Humanities So White? or Thinking the Histories of Race and Computation.” McPherson’s attempt to knit together “discussions of race (or other modes of difference) with our technological productions within the digital humanities (or in our studies of code),” depends on drawing parallels between the development of MULTICS (and then UNIX) and the more or less contemporaneous Civil Rights events of the 1960s. Her case rests strongly on the notions of modularity and encapsulation, which she presents as something akin to code apartheid. McPherson opines “I am not arguing that the programmers creating UNIX at Bell Labs and in Berkeley were consciously encoding new modes of racism and racial understanding into digital systems.” She states her purpose as showing “the ways in which the organization of information and capital in the 1960s powerfully responds across many registers to the struggles for racial justice and democracy that so categorized the United States at the time.” In pursuit of this goal McPherson sketches two historical fragments drawn from the history of the 1960s: the first is a potted history of the development of UNIX, “well known to code junkies and computer geeks,” while the second, familiar to “scholars of culture, of gender, and of race like the members of the ASA”aconcentrates on the “struggles over racial justice, [and] antiwar activism” going on at the same time2016..

For two Y1 receptor heterodimer combinations (with the Y4 receptor or 2 adrenoceptor), agonist and antagonist pharmacology was explained by independent actions on the respective orthosteric binding sites. However, Y1/Y5 receptor BiFC dimers, compared with the constituent subtypes, were characterized by reduced potency and efficacy of Y5 selective peptide agonists, the inactivity of Y1 selective antagonists, and a change from surmountable to nonsurmountable antagonism for three unrelated Y5 antagonists. Thus, allosteric interactions between Y1 and Y5 receptors modify the pharmacology of the heterodimer, with implications for potential antiobesity agents that target centrally coexpressed Y1 and Y5 receptors to suppress appetite..

Regulators also torched any hope that investors will be protected by a requirement that advisers operate under a “best interest” standard, which was the preferred way of saying a fiduciary duty to put clients first. Ontario and New Brunswick alone had shown a commitment to a best interest standard. Now, all provinces are onside with rules that avoid an overarching best interest rule..

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